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What is a package insertA package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumersA package insert typically includes information regarding specific indicationsadministration schedulesdosingside effectscontraindicationsresults from some clinical trialschemical structurepharmacokinetics and metabolism of the specific drugBy carefully reviewing the package insertyou will get the most complete and current information about how to safely use this drugIf you do not have the package insert for the drug you are usingyour pharmacist or physician may be able to provide you with a copy.
Chickenpox and measles can have a more serious or even fatal course in pediatric and adult patients on corticosteroidsIn pediatric and adult patients who have not had these diseasesparticular care should be taken to avoid exposureThe contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not knownIf exposed to chickenpoxprophylaxis with varicella zoster immune globulinVZIGmay be indicatedIf exposed to measlesprophylaxis with immune globulinIGmay be indicatedSee the respective package inserts for VZIG and IG for complete prescribing informationIf chickenpox developstreatment with antiviral agents may be considered.
In post-marketing experiencethere have been reports of both increases and decreases in phenytoin levels with dexamethasone co-administrationleading to alterations in seizure control.
After a favorable initial response is notedthe proper maintenance dosage should be determined by decreasing the initial dosage in small decrements at appropriate time intervals until the lowest dosage that maintains an adequate clinical response is reached.
Use of oral corticosteroids not recommended in treatment of optic neuritis and may lead to increase in risk of new episodescorticosteroids should not be used in active ocular herpes simplex.
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