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Given that piroxicam has been shown to be associated with an increased risk of gastrointestinal complicationsthe need for possible combination therapy with gastro-protective agentse.gmisoprostol or proton pump inhibitorsshould be carefully consideredin particular for elderly patients.

During concomitant use of FELDENE and ACE-inhibitorsARBsor beta-blockersmonitor blood pressure to ensure that the desired blood pressure is obtainedDuring concomitant use of FELDENE and ACE-inhibitors or ARBs in patients who are elderlyvolume-depletedor have impaired renal functionmonitor for signs of worsening renal functionsee WARNINGS AND PRECAUTIONSWhen these drugs are administered concomitantlypatients should be adequately hydratedAssess renal function at the beginning of the concomitant treatment and periodically thereafter.

Inform patients of the warning signs and symptoms of hepatotoxicitye.gnauseafatiguelethargydiarrheapruritusjaundiceright upper quadrant tendernessandflu-likesymptomsIf clinical signs and symptoms consistent with liver disease developor if systemic manifestations occure.geosinophiliarashetcdiscontinue FELDENE immediatelyand perform a clinical evaluation of the patient.

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