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In patients with advanced diseaseLetrozole therapy should continue until tumor progression is evident.

Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.

To determine the efficacy of Letrozole plus Imatinib Mesylate in patients with ER and or PgR positive metastatic breast cancerEfficacy will be measured by the rate of clinical tumor responseTo determine the safety and tolerability of Letrozole plus Imatinib Mesylate in patients with metastatic breast cancerTo determine the time to disease progression and overall survival in patients with metastatic breast cancer who are treated with Letrozole plus Imatinib Mesylate.

For use as extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy2.5 mg tablet orally administered once a day without regard to meals.

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