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Colofac is an antispasmodic of myotropic actionIts main constituent is MebeverineHas a direct effect on the smooth muscles of the gastrointestinal tractThe preparation eliminates spasm without affecting normal intestinal motilityIt does not possess anticholinergic actionThis formulation allows dosing schedule 2 times a day.

Mebeverine violates the entrance of Naions into the cell by preventing the fast sodium channels myocyte cell membranealso it blocks the entering through the slow channels of ions Ca2hinders the process of depolarization of the cell membrane and prevents the reduction of muscle fibersMebeverine does not have an anticholinergic actionIt directly relaxes smooth musclemainly in the gastrointestinal tractThe preparation eliminates spasmwithout exerting a significant effect on the normal intestinal peristalsis.

While each class of diuretics has its own set of side effectssome adverse effects are shared by all diuretics.

In appointing of the preparation during pregnancy must be weighed the profit to the mother and the possible danger to the fetusWhen administered in therapeutic doses Mebeverine does not penetrate into breast milktherefore its usage during lactation is allowed.

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